Hmmmm.
I'm one of the 1000 hr plus pilots.... and I’m still not having many bites.
As for e-mail CV versus posted and knocking on doors.... I have done all three. It looks like different companies have different preferences. I've kept a running log of who and when I've contacted operators and what (if any) was their response. This I found helped formulate a plan as I tend to try to cover my options.
None the less, some airlines seem to like the monthly phone call, others have virtually set up a restraining order! (well almost).
So to sum up, I would vary your approach and hopefully one will strike gold!.
Good luck