Depends to a large extent where you live, and what sector you are in. For multi-engine multi-crew qualified people in the UK, Netherlands, Germany, Denmark and Norway there is offshore work where it becomes more of a rostering limitation (and a potential recruitment consideration).
Elsewhere, there is a significant reliance on single-pilot charter for CAT operations. If this is your line of work and you are freelance, or don’t have a good sick pay scheme, you may be out of pay for some time…