ORAC: from your link, the question is "how" but I agree with the "what."
The United States should exploit Iran’s current vulnerability and weakness to push back on the Axis of Resistance in Iraq and Yemen.
Doing so would include increasing support for—rather than abandoning—Iraqi leaders who wish to see their country independent of Iranian influence and subversion.
It would also include destroying the willingness of the Houthis to continue attacks on international shipping rather than conducting intermittent airstrikes on their capabilities.
Ceding Iraq and Yemen, on the other hand, would allow Iran and its Axis of Resistance the space and time to recover.
Tehran and its allies may be down. But they are just as committed as before to attaining regional hegemony, destroying the Israeli state, and expelling American influence from the region. The United States and its allies and partners in the region should capitalize on the positive momentum created by the fall of Assad.