Done both in two flag carriers - what suffers is not only your health but family relationships; after nesrly getting divorced for a second time I spent £300 a month (1980s) on telephone calls, got an au pair and took my wife along on trips to keep our marriage going. My health suffered and I eventually lost my license. Whilst conditions change fatigue is a huge problem and in my last year I had two months unpaid leave on top of another 47 days which we used for a month sailing holiday and normal home life.
SH was basically 5 on 3 off with early first day, 3 nights away and late last augmented by 4/2 and 6/3. Long haul was 8 days off a month and up to 17 day trips. Some of my mates did mixed which seemed better.
Short haul was fun flying but that was in the days of turning everything off and doing a split arse visual..long haul was system management with a flow of interesting pax in the cockpit to break the boredom of choosing from the first class menu.
Both short and long haul can be fun but as you get older you loose your resilience- many the nights I’ve spent on the loo or leaning over it.