Well worth banging it out to everybody, although when some companies advertise a vacancy with a specified minimum of a type rating and x number of hours, they do get a little cheesed off when they receive a million cv's with nothing like the experience required.
However, that said I have a number of friends in jobs where they had less than the specified minimum - lucky them.
I wouldn't worry too much about operators who only have larger jets (767, A300 and the like), as you are unlikely to have any chance of getting in at all. Turboprops are your best bet, and some 737/scarebus operators will occasionally take pity on low hours guys too. I even know of one 757 operator who recruited someone recently in roughly your position.