I had a problem when first driving a car in the US, while on a sim course from Oz.
My sense of direction is very reliable - at home. I knew I had to go north from West Palm airport to get to the hotel, but my solar nav system hadn't been reset, so I turned the wrong way every time. It took a huge mental effort to force myself to go in the "wrong" direction to get to any desired target.
I have never had to operate an aircraft in the northern hemisphere, lucky I suppose.