Being an ab-initio with just over 200hours, I waited almost 2 years for my first job...and whilst waiting I think the best thing was to work for an airline in the office. Not only did I get to know the airline inside out but it got me that first jet job once I knew the right people and once vacancies arised.
I am now flying the 757 !! and of course you need luck on your side, to be at the right place at the right time but if you work hard and target the right airlines it is certainely possible! keeping current is also important.
best of luck!