There are 4 'highway runways' in Cyprus (at least that's all I've found but there may be more) near (ie a few miles from) Nicosia, Larnaca and Paphos so it's all been done before.
The central crash barriers are removeable and the roadsigns have huge hinges to allow them to be folded flat.
We all know about the Jaguar landing on the motorway near Warton, but I understand at least one stretch of the A1 just north of Woolfox Lodge (disused Bloodhound site) was evaluated but never implemented.