Hi Tony,
If they are removed via HijackThis, then as far as I'm aware, there should be no problems with any of your other settings.
I'm in the process of fixing a machine on another forum, and she's got at least 3 trojans/viruses, a couple of adult diallers, CWS, a couple of dozen host file redirects, and a whole bunch of other spy/ad/malware.
The complaint.. changing homepage.
If you have problems, then you might want to do the following..
Please download 'Hijack This!' from
here, unzip, doubleclick HijackThis.exe, and hit "Scan". When the scan is finished, click "Save Log", and copy and paste it in a reply.
Don’t fix anything yourself yet, as a lot of the stuff on that list will be harmless or required. It'll show up stuff you probably never knew existed.
Cheers
Liam