It's been quite a while since the USAF UAV community engaged in air-to-air fighting against Russian-built fast jets. In the 2002 example the AIM-92 fired from the Predator crossed the inbound path of the AA-6 fired from the MiG-25. The one who shot first (and with a considerably longer range) won the day, with the MiG-25 achieving the kill.
Time moves on and Reaper has replaced Predator and the AIM-9X replaced the gutless AIM-92 as the principle defensive missile. Belligerents being stupid does not, on its own, equal more forceful tactics or even lead to weapons carriage. If the RF was tempted to make a more deliberate effort to destroy another nation's military equipment, manned or not, the US would have the right to protect its assets. It was ever thus - nothing has changed.