Wiley Post was a one eyed pilot, flew the first earth circumnavigation in a single engine aircraft and was the developer of the first practical pressure suit for high altitude flight
I used to fly with two pilots in the RAF who only had one eye each
We had two chaps who when they flew together had a pair of hands between them. One had lost the fingers on one hand through a farming accident, the other had lost the fingers on one hand when he landed on a booby trapped artillery shell.