Yes,
Vertical separation no less than 1/2 of the applicable vertical separation minima, i.e. 500ft to areas up to FL285 and 1000ft to areas above FL285.
Lateral separation is a bit less straight forward:
None required for IFR in Class G or VFR in any airspace class.
1NM to areas wherein there is no flying activity (or where any flying activity is limited to UAVs at or below 120m AGL).
2.5NM to areas wherein there is military flying activity controlled by fighter control or another ATSU.
3NM to areas with flying activity that is not controlled by anyone (soaring sectors, military flying without fighter control etc.).