Dewdrop
It can't be out of trim if you are merely turning the trim wheel.
The elevator trim is a control system which maintains airspeed; ie it sets the speed at which the aircraft will fly. (I think it actually controls the AOA but that is equal to airspeed, for a given configuration)
An aircraft is out of trim if you are pushing/pulling the yoke.
It is frowned upon by instructors but I can't see anything wrong with making small altitude adjustments with the trim wheel, and airspeed adjustments SHOULD be done with the trim wheel, otherwise if you lose concentration the IAS will drift back to whatever the trim as set to, and if it was miles out that value could be too low...