Any Major US airline job would be like winning Lotto. (Called Legacy Carriers these days, Majors 30 years ago)
Don't focus too much on where you would like to live, bases come and go and you can commute, easy commute sometimes.
Driving 4 hours for AA may be a bit much as you will be on reserve initially (How do I know?
)
Even as a line holder 4 hrs drive is much: (Come back from a long overnight trip, throw in a delay and some bad wx, you been
up 20 hours, now you drive home another 4 hours, not a good idea.)
JetBlue and Spirit would be good choices, Frontier also, no A-320 time required, but common sense says it is an advantage.