Jet Airways also had substanial volumes on their own scissors hub at BRU but again, lost money, and they've since gone bust. Classic example of connections being done at a loss would be the once great British Midland who became the ***** of every STAR ALLIANCE codeshare carrier possible and still couldn't make real money.
MAN is not a natural hub, it lacks an anchor network carrier, (not a criticism of MAG). So any Pakistan/Indian traffic VS could feed onto it's US services would be arguably cannibalising their own LHR base. I think there's scope for a point to point holiday network to LAS/BOS/LAX or SFO in summer but not sure that'd scale up to year round, could be done with one based aircraft, 2 x LAS, 2 x BOS, 2 x LAX/SFO?