Douglas bader
In the 70s he did a study and a report on fatigue and flight time limitations whose recommendations were watered down by the CAA or Board of Trade so very little changed. This wasn't helped by management fiddling them. We had a night Nicosia return which could not be operated legally if rostered but could if from airport reserve. The word went around and the captain on the one I was due to operate went sick.
Unfortunately we voted in a union rep who sold us down the river then resigned and went straight into management.
Used to do a Zurich Atlanta but in winter with the stronger winds on the Nat Tracks it required a double crew so the published schedule was changed.. we went with a normal crew and arrived an hour late...worse was pick up for the return flight when they pretended it was on time so we had a couple of hours sitting in departures waiting for the aircraft to arrive and be serviced.