Single-Pilot airliners are not as far away as you would think, after-all what is the fundamental difference in operating a single-pilot business jet vs a single-pilot certified airliner?
Yes, they are a l o o o ng way off.
The difference, certification rules and about 150 plus people down the back who want someone up the front engaged in getting there safely, even if one is incapacitated.
If automation is so READY then why do we only have Autoland which has been around forever but no auto take off? Ponder that.