Nicest handling piston twin - Aerostar by far. Then Aero Commander. C414A nice & safe if un-exciting.
Never felt relaxed in Chieftain for some reason.
Worst - Seneca 1. What a total ****-box. Later models marginally better.
Single - haven’t flown Chippie etc., but of the usual GA stuff only the C210 had nice handling (haven’t flown a Bonanza but suspect that’d be the only one that would be as good or better).