Imho there will always be a human in the flight deck, maybe not a pilot the job may be entirely re designed but it will be a human employed by the airline. Someone needs to be to blame when things go wrong. You will always have accidents, do Boeing and Airbus really want to be the sole party to blame for every accident. 2 max crashes have led to $3bn lawsuit for Boeing so far?
The other issue will be government and airspace restrictions. Regulation is very slow moving. Unionised countries will put a break in the road. Take France up until a decade ago no one over 65 could land there. Now the updated rule is one pilot must be under 60. Or take regulations around medical issues and MOLs on your licence, only one of you being allowed one.
Airlines might push hard for this, but I can’t see governments being that receptive until a lot of proof of concept. And even then you’d have to convince all governments.