It really depends on what you call safe.
In the earlier part of the 20th century people flew everwhere, companies made profits but planes quite "often" crashed.
In this age, planes crash way less often, but they still do, often because of avoidable reasons. Still companies make profits, people fly.
Everything we do in life can be safer, from driving a car to baking a bread, from flying a plane to building your house.
It is always a cost-risk balance. If we did everything as safe as technology and psychology would allow us, things would be unpayable and take way longer to produce.
All our rosters, airplanes, procedures, training are a result of that balance. I think I can succesfully argue that flights between 9am and 5pm are safer than a redeye/through the night flight (which doesn't say those are unsafe), and that most flight would be even safer with 3 pilots up front than 2, but we still regularly take the cheaper, easier to plan "less safe" option.
It is all about where you (we) place the lower limit of what we call safe.And that is also a regional thing. While in the US a ferry service is subject to numerous rules and regulations to achieve a level of acceptable (un)safety, in certain other countries they are way more happy to board a rickety vessel knowing full well they often capsize or sink killing 250 people. And still, those companies are in business.