ULR freighter only?
If you carry freight without passengers over 6000 NM the two leg one stop in between will always win over the non stop transport in fuel burn. So why use an ULR freighter with its excess structure material which does not pay. With passenger transport you have a mixed calculation and some freight can pay non stop. But for a freighter I don't see the point. I would assume, that a 380 as 4 holer will become expensive to maintain quick, compared to other 2 donkey options.