Can you use the rudder on large jet transports in the same way you might use it on a light aircraft? Yes. Do you need to? No, not really, outside of asymmetric conditions or deliberate crossed controls. I admit to a bit of top rudder turning visual finals with an empty aircraft, just for the fun of it, but I don’t think it would impress passengers.
On modern jets, especially FBW ones, there are all sorts of things going on underneath the skin that obviate the need for rudder inputs in normal flight, so you’ll just end up fighting those systems...