rog747 - I'm not sure that TCI would count as a 'major airport', except that night, when it was very unusually, and excessively, overcrowded.
The single runway was only one of several 'holes in the cheese' that resulted in the crash; a parallel runway wouldn't even necessarily have prevented an accident under those conditions - under which, as you say, the airport shouldn't even have been operating. Apart from the ones you've mentioned, an important 'hole in the cheese' was the impatience of the KLM captain who attempted takeoff in appalling visibility, such that he couldn't see a 747 backtracking towards him although he knew it was there, without making certain that it was clear of the runway (it wasn't, of course), and despite the attempt of the more experienced, but junior, flight engineer to warn him.