I suppose another way of coming at the question of "A modern VC 10" would be to ask what could be designed now to have the same appeal to passengers as the VC 10 obviously had in comparison with its contemporaries.
Apart from the question of British manufacture, which would not be important in most markets, what I hear is especially passenger comfort, starting with quiet. That, unfortunately, sounds rather like the A380. But is there any difference that could be made that would be better than simply improving the seating on a truly modern aeroplane?