The thing is, that in the years before COVID, there were the opportunities... Gatwick, London City and Manchester. With no need for Leeds/Bradford and Norwich meaning a smaller fleet would have been needed.
In the post Flybe era, Birmingham also materialised, so East Midlands should have been dropped.
In the post COVID era, there could be Gatwick, ( I can see a BA presence there in future ), Birmingham and Manchester. Maybe Heathrow and / or LCY could be added. If there is a real need for Southampton then so be it, and of course Alderney. So, in short, Alderney, Gatwick, Manchester and Birmingham. Possibly Southampton, and Heathrow and/or LCY. Scrap the other routes.