Eurocontrol IFPS do not check NOTAMs. If your flight plan fits the format , and the route is free of restrictions , if will be accepted and sent off..
Reading and complying with NOTAMs is the PIC responsibility ..In this case OPS and the dispatcher missed it, but the buck stop with the PIC..
That said, as mentioned before , the German DFS NOTAM system is totally out of reality . These Yemen or Somali NOTAMs on airspace being closed are popping up even on a PLN Frankfurt to Amsterdam .
But only typing LIEO NOTAM in google on your smartphone would show you the relevant destination NOTAMS in 2 seconds...