I'm with Richard in recommending Mailwasher Pro. It's quite fabulous and there's a set of filters that you can download from
here and then tweak and personalise. (You don't need to do much of either, but you can if you want.)
As default options, Mailwasher can use
Spamcop's public blacklist and
ORDB's database of open relays. You can add other remote blacklist servers to which you subscribe if you wish.
You can also subscribe to Mailwasher's own database of spam, called FirstAlert.
I said in another thread a month or so ago that I get about 200 spams a day and at the time had reduced that by about 90%. I get more than 200 a day now. Despite the extra crap, tweaking filters and other Mailwasher settings has improved the spam cut to pretty much 100%.
As with any spam filter, there is the risk of false positives (since tweaking the filters it's pretty infrequent), but there are options within Mailwasher to help you deal with that.
It is a very, very good program.
AA