During WW2 it was the norm on british 4 engine bombers to have just One Pilot,the Bomb Aimer or Flight Engineer might have been capable of flying the Aircraft in an emergency or to let the pilot visit the ELSAN - either due to previous training ('washed out' of pilot training in many Bomb Aimers case) or because of being given some 'stick time' by the Pilot.
Up to and including the Hawker Hunter the cockpit layout was usually very non ergonomic,after that things improved significantly.
I never worked on 'Heavies' but ISTR that the Victor Flight Deck seemed quite neat and orderly (as seen by me as an Air Cadet circa 1966),The Vulcan Flight Deck was a little cramped as it had originally been designed for single pilot operation.