The only stopper for refuelling a V22 would be the AAR speed -is 180 KCAS too fast for a V22 and where is the evidence that a KC46 could do it any slower?
From Omega Air Tanker on 1 Oct 2018:
This week, Omega completed a long-range overwater aerial refueling “drag” mission that brought eight VMM-268 MV-22B Osprey tilt-rotor aircraft from Guam to their home station of MCAS Kaneohe Bay, Hawaii after a successful MRF-D deployment.
On the first of two legs, Omega dragged all eight MV-22Bs to Wake Island. On the second leg, Omega made two trips, dragging four MV-22Bs each time - over 2000 NM legs over open ocean.
These are the first steps for Omega to conduct ops that can help us ensure the Marine Corps can rapidly deploy across the Pacific and Atlantic Oceans with their MV-22B aircraft.
We will continue to evolve this capability and grow our operating methodology. Planners and operators’ warmest congratulations on this historic mission. What an awesome trip with the Marines!
They used a 707 with centreline hose for the mission.