I've tried using mine once as a replacement for the main VHF (because it's an old model and the squelch is hopeless; it was annoying me so I switched to the handheld unit). That was with a headset adapter. What I found was that a lot of people immediately complained that my transmissions were garbled. I suspect that's a fairly common result when you use a fairly low-powered transmitter and stick your antenna inside a big metal box.
I imagine that if you had a way to wire it to the external antenna (or if you have a second external antenna wired for exactly this purpose) then it would work much better.
I still keep it in the plane as an emergency backup (and it's good for things like getting the latest weather information before starting the engine, communicating with people when you're not wearing the headset, etc) but I wouldn't use it as a fix for an annoying-but-not-critical problem in the future.