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Old 14th Feb 2020, 17:01
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Peter H
 
Join Date: Jun 2008
Location: Cambridge UK
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Anybody have information on any link between 2019-nCoV and "cytokine storms"? I'd sort of assumed there would be,
but the high average age of the fatalities suggest not.

https://www.scripps.edu/news-and-eve...tonerosen.html
A cytokine storm is an overproduction of immune cells and their activating compounds (cytokines), which, in a flu infection, is often
associated with a surge of activated immune cells into the lungs. The resulting lung inflammation and fluid buildup can lead to
respiratory distress and can be contaminated by a secondary bacterial pneumonia—often enhancing the mortality in patients.


This little-understood phenomenon is thought to occur in at least several types of infections and autoimmune conditions, but it
appears to be particularly relevant in outbreaks of new flu variants. Cytokine storm is now seen as a likely major cause of mortality
in the 1918-20 “Spanish flu”—which killed more than 50 million people worldwide—and the H1N1 “swine flu” and H5N1“bird flu” of
recent years. In these epidemics, the patients most likely to die were relatively young adults with apparently strong immune

reactions to the infection—whereas ordinary seasonal flu epidemics disproportionately affect the very young and the elderly.

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