The biggest difference I’ve found between flying for fun and flying professionally is that as a CPL you no longer get to choose your destinations which as a control freak, can be a bit of a downer. As a GA CPL, I would visit our main destination up to 6 times a day. As a regional turboprop FO, I visited the same airport over 400 times in a year. As a long haul jet pilot I have visited Anchorage, Alaska. The first few times were pretty interesting. After about the 100th visit in the middle of a cold, dark winter, not so much.