I've flown an SR22, mainly out of interest to see how the instrumentation worked. All of the cruise flying was done using the autopilot, but I did three takeoffs and landings and an ILS and go-around, which was flown by the autopilot with me adjusting power to stay on the glide slope - there is no auto throttle.
I found it very easy to fly on both takeoff and landing. I felt I would only have needed an hour or two of upper-air work and circuits to be completely comfortable. The instruments, on the other hand, were a different issue. My instructor said it usually took at least 10 hours to become at home with operating the systems.
I thought it was a very nice aircraft but I don't think that if I had the money, I would invest in one.