If you're with QF or Virgin I would be very reluctant to give that up as with 10 000 hours I'm assuming you're well into your 30s and past the point where you want to start at the bottom of the seniority list again with another legacy airline. Where you to go and come back relatively soon then you're looking at starting at the bottom again IF you get reemployed. A low cost in the UK might be your best option as you would probably get a quick upgrade with your experience level but then you will probably have to stay there unless you fancy China or the Middle East for an airline career. Returning home later on as a Captain could give you a shot at Alliance or Cobham as a direct entry skipper but obviously on far worse terms than you'd have if you upgraded with your current employer.
Unfortunately our profession doesn't favour mobility between employers.