Will Atlas 3591 turn out to be yet another widebody freighter loss due to 'human factors'? Is a higher accident rate acceptable for cargo planes since the crashes cause 'no significant loss of life'?
Unfortunately, the first part is probably true, the second part is definitely true. The regulators
have made a conscious decision to allow freight operators more risk - it's encoded in the regulations (and the FAA isn't alone here, EASA has similar differences). One blatant example is the rules for extended diversion time operations. The extended diversion time rules have been applied to passenger aircraft with more than two engines, while freight aircraft with more than two engines are specifically exempted.