The actual flying and feel cannot be simulated using some tiny PC. However basic IFR skills, scan patterns and such can. Just look how simple the very capable Link trainer had been in and after WW2. So doing VOR patterns at night against the wind for practice might be more useful than not flying at all during the winter or similar. That goes for not too complex singles and maybe light twins.
It's still important to stay aware what needs to be trained in real life with some instructor.