The amount of force isn't for a long period of time, that's what the trim is for. But on rotation the trim is set for takeoff power and V2. Do a de-rated, flex, assumed, takeoff? The force to rotate is higher. You're also below V2 which means the plane is out of trim by how much Vr is less than V2 (maybe 5-10 kts). The 757 pitch force going from full power takeoff to a 2,000' level off, where the power almost goes to idle, is very heavy. Smaller people might need two hands. Larger people don't but many use two hands.