Sims are fairly close to the real airplane but not exact. I think the sims are flown by CKA 2x(?) a year to verify that the 'feel' is similar to the real plane. Boeing 757 is the heaviest in the pitch. 767-300 is lightest. 737NG and 777 are somewhere in between. Heavy in pitch? I see 250 lbs (110 kg) guys flying with both hands and 105 lbs (50 kgs) women flying with one hand. Two hands is a unnecessary technique. Randomly it might be necessary, like a low altitude level off in a 757. The pitch force to counteract the thrust reduction is very high (30, 40, or more lbs of pull?)(tdracer might know the force).