You bet! I know plenty of guys using active noise headsets (Sennheiser is the best) on the A320 or 330 series. I tried that too and it is fantastic, just cutting out the aerodynamic noises.
I use the same on the ARJ everyday and sure would not fly without, at least up to FL240 when the noise becomes bearable.
Any Embraer 135/140/145 pilots out there? Heard this bird is very noisy in pointed end
?
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... cut my wings and I'll die ...