As a North American freighter new-hire you will be given a choice of whatever base is available at the time in your base area (North America). Currently, I believe LAX, JFK and ORD are available for F/O's. I have not seen ANC open for F/O's or Capt's for a couple of years. Not sure why as ANC is obviously a hub for the freighter operation. I know in the past year a couple of pilots have requested to move to ANC and were turned down.
Your schedule/roster is sent to you by the 15/16 of every month for the following month. You have VERY LITTLE input to the roster. Requested days off are sometimes granted but more often NOT. You have a JOKER option, 1 every six months, when you can specify up to 5 days off in a row with 100% assurance if you follow a few rules.
You can remain on freighters until a freighter command is available and avoid passenger flying but since a USA based passenger F/O makes the same as a freighter Captain, you just may reconsider.
Good luck