It’s an interesting situation because on most days of the year you’ll see QF 94 coming in from LA to land to the north as it flies over the CBD on base. That would be presumably as you can’t land a 380 on the east west runway.
It it feels like parallel north-south runways would be best for most conditions, as Melbourne does get south-westerly sea-breezes pretty much every day in summer. The residents aren’t going to be very happy !