I've seen Spitfire replicas running LS v8s and Isuzu V6s so it already been done for a while.
I'm not that familiar with them but the first I saw was about 10 years ago and I assume the kits are still being built.
Google says they are good for 250-430 HP, if you need more power you probably need a second engine or a turbine rather than a relatively obscure piston car engine with four digit HP figures.