It’s a bit hard to have data of long term effects on things that are new
.
We have current evidence that demonstrates that current tours-of-duty up to (and occasionally beyond) 20 hours are problematic. Yes, these are usually on an unplanned basis but the impact of of these duties is known. It is essential then, that every avenue be explored before a commitment is made to regulating planned 22 hour ToD's with an available extension to 24. That's what will be needed to crew JFK-SYD/MEL and SYD/MEL-LHR.
Like most shiftworkers part of a pilots pay reflects an unavoidable downside attached with working unusual hours.
….And whilst money
apparently makes fatigue go away
the difference between a ground-based shift worker and a Pilot, is the ground-based employee usually starts about the same time every shift for at least a fixed period, in the same location and doesn't suffer from longitudinal displacement among numerous other differences.