Just adding a few bits.
Some of the Airbus fleet have long been approved for 40% thrust reduction.
V1 will be limited by VMCG(toga) whereas you would Flex a lot and possibly have an increased V2 schedule too. V1 choice from the V1 range has three obvious options in most of the software (including the one that prints the RTOW tables).
- V1 max
- V1 min
- V1 mean
- V1 range.
There is a minimum weight AFM limit on some of the Airbus configurations.
160 kt to 4DME in CONF 1 is a once in a lifetime idea.