Arrivals to the Southerly runway ( 21) always an issue in poor weather due to terrain allied to the fact its not a particularly long runway. ILS approach to 03 should not be an issue unless you are unlucky enough to arrive in torrential rain and/or turbulence or crosswinds on or above limits. Departures on 03 can be a problem for the 737 depending upon conditions requiring a 21 take-off against the traffic flow. 757 usually has no performance issues at all so its just a question of weather unless you are at the back end of an arrival stream.