Arthur D, it is almost as if you believe that if all the regulations are followed that aviation will be “safe”. Nothing could be further from the truth.
For example, look at ETOPS operations. Under ETOPS there can be an engine failure and the aircraft can keep flying as a single engine aircraft for many hours to landing. Is there a chance that the second engine could fail? Of course there is. If this is over a remote ocean at night, the consequences will be serious.
One day it will probably happen because the ETOPS equation is based on probability.