As US legacy hub carriers will tell you, frequency trumps all.
True, but is the worlds largest airplane the answer? Two/day A380s - which you may not be able to fill, or three/day big twins? And if you can't always fill three big twins because of seasonal changes, you can drop it down to two/day when things are slow, then increase back to three when the demand recovers.
Don't get me wrong, from a passenger perspective the whale is a wonder aircraft - but from an operator standpoint it only makes sense if you can consistently fill it. For a long time, operators needed the 747 because it was the only way to get the range. But for the last decade or so, big twins have had range equal to the big quads, with better operating economics, and passenger 747s have been slowing disappearing, replaced not with the A380 but with big twins.
Few people see than changing in favor of the A380.