With the fuel savings of the A220/C Series, I think Neeleman could give the more established carriers a good run for their money. Plus it doesn't look like he's planning to start small - the order is for 60 of the larger version. Unless the majors start breaking their hub and spoke model and begin offering non-stop flights between smaller cities, I'm not sure how well they can compete if a passenger values time and does not want to take a connecting flight.