There must be a physical limit to the size of an aircraft design, in relation to the possible turbulence forces that an aircraft may encounter.
Yes
A380 Too Big, Massive Inertia Factor!
No. I think Airbus might have thought of that.
Weather and wake turbulence forces striking an aircraft are unable to accelerate a large mass into motion
Newtonian physics would suggest otherwise.
An example of this phenomena is the TWA 800 accident. (Another massive structure.) At 2031.12 the aircraft was initially struck by wake turbulence forces that started the structural breakup
Completely unproven.