Twin engined aircraft are much cheaper to operate and have the same or better range than four engine models. Bye bye 747 and 380 aircraft.
I wouldn't be so hasty to write off the 747-8F just yet. I suspect the Big Bird will still be flying around in some form long after most of us have shuffled off this mortal coil. I was at the Everett plant last month and the integration of the 747F & 767F lines was most impressive. If Boeing can keep the 747 line going this next 24 months (and it looks like they can), the medium-term economic outlook for large freighters looks pretty rosy... certain politicos notwithstanding.